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Aryl hydrocarbon receptor repressor

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Protein Overview: Aryl hydrocarbon receptor repressor

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.

Synonyms: AhR repressor, AhRR

Gene name: Ahrr

Database References

UniProtID GeneID
Mus musculus Q147Z5 11624
Rattus norvegicus Q75NT5 498999
Homo sapiens A7MBN5 57491

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017