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Arylacetamide deacetylase

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Protein Overview: Arylacetamide deacetylase

Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.

Synonyms: 50 kDa microsomal esterase/N-deacetylase

Gene name: AADAC

Database References

UniProtID GeneID
Homo sapiens A8K3L3 13
Rattus norvegicus Q9QZH8 57300
Mus musculus Q8VCF2 67758
Oryctolagus cuniculus Q7M370
Bos taurus Q0P5B7 519557

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017