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Protein Overview: Ataxin-1

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.

Synonyms: Spinocerebellar ataxia type 1 protein homolog

Gene name: Atxn1

Database References

UniProtID GeneID
Mus musculus P54254 20238
Homo sapiens P54253 6310
Rattus norvegicus Q63540 25049

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017