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Protein Overview: Ataxin-1-like

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1).

Synonyms: Brother of ataxin-1

Gene name: Atxn1l

Database References

UniProtID GeneID
Mus musculus P0C7T6 52335
Homo sapiens P0C7T5 342371

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017