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ATP synthase-coupling factor 6, mitochondrial

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Protein Overview: ATP synthase-coupling factor 6, mitochondrial

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

Synonyms: ATPase subunit F6

Gene names: ATP5J, ATPsyn-Cf6

Database References

UniProtID GeneID
Pongo abelii Q5RBY3 100172310
Bos taurus P02721 282690
Crab-eating macaque Q8SPH6
Drosophila melanogaster Q24407 42759
Sus scrofa P13618
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017