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ATP synthase subunit alpha, mitochondrial

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Protein Overview: ATP synthase subunit alpha, mitochondrial

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.

Synonyms: Protein bellwether

Gene names: ATP5A1, ATPA, atp-1, atp5a, H28O16.1, blw

Database References

UniProtID GeneID
Leadwort-leaved tobacco P05495
Arabidopsis thaliana P92549 3890462
Pongo abelii Q5R546 100173854
Oryza sativa subsp. japonica P0C522 6450183
Bos taurus P05629 282578
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017