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ATPase asna1

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Protein Overview: ATPase asna1

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.

Synonyms: Arsenical pump-driving ATPase, Arsenite-stimulated ATPase

Gene name: asna1

Database References

UniProtID GeneID
Zebrafish B8A663 325704
Mus musculus O54984 56495
Caenorhabditis briggsae A8WNH9 8571704
Homo sapiens A6NHP8 439
Xenopus laevis Q6GNQ1 444297
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017