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ATPase family AAA domain-containing protein 2

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Protein Overview: ATPase family AAA domain-containing protein 2

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Synonyms: AAA nuclear coregulator cancer-associated protein, ANCCA

Gene name: ATAD2

Database References

UniProtID GeneID
Pongo abelii Q5RDX4 100174282
Homo sapiens Q14CR1 29028
Mus musculus Q3UYW6 70472

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017