auto
Find a product

ATPase GET3

(Browse other proteins)

See products

Protein Overview: ATPase GET3

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Synonyms: Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3

Gene name: GET3

Database References

UniProtID GeneID
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) P0CM24 3254436
Yarrowia lipolytica (strain CLIB 122 / E 150) Q6C3M9 2912854
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) Q4WY07 3512551
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) B6H443 8317486
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) B9W757 8044464
[+] See all

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017