This section lists products related to this protein that have the highest publication record. We only include products that we can verify to be exact product used in a particular paper.
|1.||Abcam #ab1287 Polyclonal Rabbit anti-AURKA antibody (8)|
|2.||Abcam #ab13824 Monoclonal Mouse anti-AURKA antibody (6)|
|3.||Bethyl Laboratories #A300-071A Polyclonal Rabbit anti-AURKA antibody (6)|
|4.||Bethyl Laboratories #IHC-00067 Polyclonal Rabbit anti-AURKA antibody (4)|
|5.||Abcam #ab18318 Polyclonal Rabbit anti-AURKA antibody (4)|
|6.||Bethyl Laboratories #A300-072A Polyclonal Rabbit anti-AURKA antibody (3)|
|7.||Abnova #H00006790-M01 Monoclonal Mouse anti-AURKA antibody (2)|
|8.||Abcam #ab12875 Polyclonal Rabbit anti-AURKA antibody (2)|
|9.||Abcam #ab58494 Polyclonal Rabbit anti-AURKA antibody (1)|
|10.||Bethyl Laboratories #IHC-00062 Polyclonal Rabbit anti-AURKA antibody (1)|
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Synonyms: Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A
Gene name: AURKA