This section lists products related to this protein that have the highest publication record. We only include products that we can verify to be exact product used in a particular paper.
|1.||Abcam #ab2254 Polyclonal Rabbit anti-AURKB antibody (23)|
|2.||Epitomics, Inc. #1788-1 Monoclonal Rabbit anti-AURKB antibody (3)|
|3.||Bethyl Laboratories #A300-431A Polyclonal Rabbit anti-AURKB antibody (3)|
|4.||Bethyl Laboratories #IHC-00003 Polyclonal Rabbit anti-AURKB antibody (1)|
|5.||Cell Signaling Technology #2914 Monoclonal Rabbit anti-AURKA, AURKB, AURKC antibody (0)|
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis. A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity.
Synonyms: Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B
Gene names: AURKB, ial
|Western clawed frog||A4IGM9||549613|
Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017