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Autoimmune regulator

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Top Rated Vendors

    average rating # of reviews # of products offered
1. Abcam 3.00 1 73,913

Autoimmune regulator Product Reviews

3 - Good (Publishable / Would use again)
Application: IHC
Sample: Human Tissue sections (Tonsil)
Buffer: N/A
Dilution: 1/200

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Protein Overview: Autoimmune regulator

Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

Synonyms: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein

Gene name: AIRE

Database References

UniProtID GeneID
Homo sapiens O43918 326
Mus musculus Q9JLW0 11634

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017