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Top Rated Vendors

    average rating # of reviews # of products offered
1. Cell Signaling Technology 4.00 2 5,879
2. R&D Systems 4.00 1 19,902
3. Santa Cruz Biotechnology, Inc. 3.00 1 43,721

Axin-1 Product Reviews

4 - Excellent (Publishable / Ideal reagent)
Application: WB
Sample: sw480 cells
Buffer: TBST
Dilution: 1/1000
4 - Excellent (Publishable / Ideal reagent)
Application: WB
Sample: Human cancer cell lysate
Buffer: BSA
Dilution: 1:1000
4 - Excellent (Publishable / Ideal reagent)
Application: WB
Sample: EMT6 cells
Buffer: TBS+Tween 0.1%
Dilution: 1/1000
3 - Good (Publishable / Would use again)
Application: WB
Sample: Human colon cancer cell lysate
Buffer: BSA
Dilution: 1:1000

Top Cited Products

This section lists products related to this protein that have the highest publication record. We only include products that we can verify to be exact product used in a particular paper.

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Protein Overview: Axin-1

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

Synonyms: Axis inhibition protein 1

Gene name: AXIN1

Database References

UniProtID GeneID
Gallus gallus O42400 395786
Mus musculus O35625 12005
Xenopus laevis Q9YGY0 398097
Zebrafish P57094 57931
Rattus norvegicus O70239 79257
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017