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Beta-adrenergic receptor kinase 1

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Protein Overview: Beta-adrenergic receptor kinase 1

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Synonyms: Beta-ARK-1, G-protein-coupled receptor kinase 2

Gene name: ADRBK1

Database References

UniProtID GeneID
Mesocricetus auratus Q64682
Homo sapiens B0ZBE1 156
Bos taurus P21146 282682
Rattus norvegicus P26817 25238
Mus musculus Q99LL8
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017