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cAMP-regulated phosphoprotein 19

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Protein Overview: cAMP-regulated phosphoprotein 19

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

Synonyms: ARPP-19

Gene name: arpp19

Database References

UniProtID GeneID
Western clawed frog Q05B03 447957
Zebra finch B5G1C4 100190388
Sus scrofa Q712U6 397362
Homo sapiens B2R497 10776
Bos taurus Q28054 282658
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017