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Centromere protein S

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Protein Overview: Centromere protein S

DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and APITD1/CENPS in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recorery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. As a component of the APITD1/CENPS complex, is also essential for the stable assembly of the outer kinetochore. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.

Synonyms: CENP-S, Apoptosis-inducing TAF9-like domain-containing protein 1 homolog, FANCM-interacting histone fold protein 1

Gene name: Apitd1

Database References

UniProtID GeneID
Mus musculus A2AH77 69928
Homo sapiens Q8N2Z9 100526739
Bos taurus Q2TBR7 613732
Xenopus laevis Q6NRI8 431958

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017