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Cyclic AMP-dependent transcription factor ATF-1

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Protein Overview: Cyclic AMP-dependent transcription factor ATF-1

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Synonyms: cAMP-dependent transcription factor ATF-1, Activating transcription factor 1, TCR-ATF1

Gene name: Atf1

Database References

UniProtID GeneID
Mus musculus P81269 11908
Bos taurus Q08DA8 506967
Homo sapiens P18846 466

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017