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Cyclic AMP-dependent transcription factor ATF-7

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Protein Overview: Cyclic AMP-dependent transcription factor ATF-7

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.

Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.

Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Synonyms: cAMP-dependent transcription factor ATF-7, Activating transcription factor 7, Transcription factor ATF-A

Gene name: ATF7

Database References

UniProtID GeneID
Pongo abelii Q5R9C9 100172894
Mus musculus Q8R0S1 223922
Homo sapiens A5D6Y4 11016

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017