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Cysteine protease ATG4A

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Protein Overview: Cysteine protease ATG4A

Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.

Synonyms: Autophagy-related cysteine endopeptidase 2A, Autophagin-2A, Autophagy-related protein 4 homolog A, bAut2A

Gene name: ATG4A

Database References

UniProtID GeneID
Bos taurus Q6PZ05 408003
Pongo abelii Q5R699 100173580
Oryza sativa subsp. indica A2XHJ5
Gallus gallus Q5ZIW7 772074
Arabidopsis thaliana O80583 819020
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017