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Cysteine protease ATG4B

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Protein Overview: Cysteine protease ATG4B

Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Synonyms: Autophagy-related cysteine endopeptidase 2B, Autophagin-2B, Autophagy-related protein 4 homolog B, bAut2B

Gene name: ATG4B

Database References

UniProtID GeneID
Bos taurus Q6PZ03 408002
Mus musculus Q6ZQ22 66615
Arabidopsis thaliana Q570T6 825165
Oryza sativa subsp. japonica Q7XPW8 4337435
Homo sapiens B7WNK2 23192
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017