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Cysteine protease ATG4C

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Protein Overview: Cysteine protease ATG4C

Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Synonyms: AUT-like 3 cysteine endopeptidase, Autophagin-3, Autophagy-related cysteine endopeptidase 3, Autophagy-related protein 4 homolog C

Gene name: ATG4C

Database References

UniProtID GeneID
Homo sapiens A6NLR8 84938
Western clawed frog Q28FA3 493268
Mus musculus B1ASJ9 242557
Xenopus laevis Q5XH30 495080

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017