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Cysteine protease ATG4D

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Protein Overview: Cysteine protease ATG4D

Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Synonyms: Autophagin-4, Autophagy-related protein 4 homolog D

Gene name: ATG4D

Database References

UniProtID GeneID
Sus scrofa Q684M2 100141400
Mus musculus Q8BGV9 235040
Homo sapiens Q86TL0 84971
Xenopus laevis Q68FJ9 447241

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017