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Cytosolic carboxypeptidase 6

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Protein Overview: Cytosolic carboxypeptidase 6

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Synonyms: ATP/GTP-binding protein-like 4

Gene names: AGBL4, ccpp-6

Database References

UniProtID GeneID
Homo sapiens B3KT26 84871
Caenorhabditis elegans Q09296 184043
Mus musculus A2A979 78933

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017