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DNA-(apurinic or apyrimidinic site) lyase 2

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Protein Overview: DNA-(apurinic or apyrimidinic site) lyase 2

Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

Synonyms: AP endonuclease 2, Apurinic-apyrimidinic endonuclease 2

Gene names: APN2, Apex2

Database References

UniProtID GeneID
Schizosaccharomyces pombe (strain 972 / ATCC 24843) P87175 2540679
Mus musculus Q68G58 77622
Bos taurus Q58D90 511790
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) D6VPY1 852262
Homo sapiens Q9UBZ4 27301

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017