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DNA protection during starvation protein

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Protein Overview: DNA protection during starvation protein

Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulation of neutrophils and monocytes at the site of infection. Induces superoxide anion generation, adhesion and chemotaxis of neutrophils, through a pertussis toxin-sensitive pathway involving MAP kinases.

Synonyms: Nutrient stress-induced DNA-binding protein

Gene name: dps

Database References

UniProtID GeneID
Escherichia coli O139:H28 (strain E24377A / ETEC) A7ZJM7 5588356
Klebsiella pneumoniae Q84FI0
Shigella dysenteriae serotype 1 (strain Sd197) Q32I91 3797884
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) B1IXF6 6065101
Salmonella dublin (strain CT_02021853) B5FP96 6875468
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017