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Double-stranded RNA-specific adenosine deaminase

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Top Rated Vendors

    average rating # of reviews # of products offered
1. Novus Biologicals 3.00 2 72,972

Double-stranded RNA-specific adenosine deaminase Product Reviews

3 - Good (Publishable / Would use again)
Application: Immunostaining
Sample: mouse cell line
Buffer: PBST
Dilution: 1:100
3 - Good (Publishable / Would use again)
Application: WB
Sample: mouse cell line
Buffer: TBST
Dilution: 1:1000

Top Cited Products

This section lists products related to this protein that have the highest publication record. We only include products that we can verify to be exact product used in a particular paper.

Protein Overview: Double-stranded RNA-specific adenosine deaminase

Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.

Synonyms: DRADA

Gene name: Adar

Database References

UniProtID GeneID
Rattus norvegicus P55266 81635
Homo sapiens B1AQQ9 103
Mus musculus O70375 56417

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017