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E3 ubiquitin-protein ligase AMFR

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Protein Overview: E3 ubiquitin-protein ligase AMFR

E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol (By similarity). Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.

Synonyms: Autocrine motility factor receptor, AMF receptor

Gene name: Amfr

Database References

UniProtID GeneID
Mus musculus Q8K008 23802
Homo sapiens Q8IZ70 267

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017