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Eukaryotic translation initiation factor 3 subunit J

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Protein Overview: Eukaryotic translation initiation factor 3 subunit J

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.

Synonyms: eIF3j

Gene names: Adam, hcr1, Eif3j, AGAP006613, CPIJ004899, v1g240395, AAEL012279

Database References

UniProtID GeneID
Drosophila melanogaster Q7K550 36037
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) B0Y762
Mus musculus Q66JS6 100042807
Candida albicans (strain SC5314 / ATCC MYA-2876) Q5ACM9 3638952
Drosophila sechellia B4IMQ8 6620822
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017