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Gamma-secretase subunit APH-1A

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Protein Overview: Gamma-secretase subunit APH-1A

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Synonyms: APH-1a, Aph-1alpha

Gene name: Aph1a

Database References

UniProtID GeneID
Mus musculus Q8BVF7 226548
Homo sapiens Q5TB23 51107

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017