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Gamma-secretase subunit APH-1B

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Protein Overview: Gamma-secretase subunit APH-1B

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

Synonyms: APH-1b, Aph-1beta

Gene name: APH1B

Database References

UniProtID GeneID
Pongo abelii Q5RDM3 100171910
Mus musculus Q3U3B5 208117
Homo sapiens A8K589 83464
Zebrafish Q8JHE9 386808

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017