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Histone chaperone ASF1A

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Protein Overview: Histone chaperone ASF1A

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Synonyms: Anti-silencing function protein 1 homolog A

Gene name: Asf1a

Database References

UniProtID GeneID
Mus musculus Q9CQE6 66403
Homo sapiens Q6IA08 25842
Bos taurus Q2KIG1 618099

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017