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NEDD8-activating enzyme E1 regulatory subunit

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Protein Overview: NEDD8-activating enzyme E1 regulatory subunit

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Synonyms: APP-BP1, Amyloid protein-binding protein 1

Gene names: nae1, uba5, AXR1, ula-1, APP-BP1

Database References

UniProtID GeneID
Xenopus laevis Q6NTW6 414612
Gallus gallus Q5ZIE6 415792
Arabidopsis thaliana P42744 839286
Schizosaccharomyces pombe (strain 972 / ATCC 24843) Q9UT93 2543075
Mus musculus Q8CFL6 234664
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017