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Neutral ceramidase

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Protein Overview: Neutral ceramidase

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

Synonyms: N-CDase, NCDase, Neutral N-acylsphingosine amidohydrolase, Neutral acylsphingosine deacylase, Slug-a-bed protein

Gene names: CDase, Asah2, At2g38010, LOC_Os01g43520, PA0845

Database References

UniProtID GeneID
Drosophila melanogaster Q7YTD8 43618
Mus musculus Q3UWP9 54447
Drosophila pseudoobscura pseudoobscura Q29C43 4800384
Arabidopsis thaliana Q304B9 818379
Zebrafish Q5W7F1 493602
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017