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Peroxisomal acyl-coenzyme A oxidase 1

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Protein Overview: Peroxisomal acyl-coenzyme A oxidase 1

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.

Synonyms: AOX 1, Long-chain acyl-CoA oxidase, AtCX1

Gene names: ACX1, ACOX1

Database References

UniProtID GeneID
Arabidopsis thaliana O23518 827381
Cavia porcellus Q9Z1N0 100135467
Pongo abelii Q5R8F0 100172283
Homo sapiens A8K6X8 51
Dictyostelium discoideum Q54GQ6 8627428
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017