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Putative Polycomb group protein ASXL2

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Protein Overview: Putative Polycomb group protein ASXL2

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.

Synonyms: Additional sex combs-like protein 2

Gene name: ASXL2

Database References

UniProtID GeneID
Homo sapiens Q53TC9 55252
Mus musculus Q3TRU9
Gallus gallus Q5ZM88 421993

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017