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Pyrin domain-containing protein 1

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Protein Overview: Pyrin domain-containing protein 1

Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Synonyms: PAAD-only protein 1, Pyrin-only protein 1

Gene name: PYDC1

Database References

UniProtID GeneID
Homo sapiens B2R8L4 260434

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017