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Rho GTPase-activating protein 17

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Protein Overview: Rho GTPase-activating protein 17

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1.

Synonyms: Neuron-associated developmentally-regulated protein, Nadrin, Rho-type GTPase-activating protein 17

Gene name: Arhgap17

Database References

UniProtID GeneID
Mus musculus Q3UDP7 70497
Homo sapiens A8K6M6 55114
Rattus norvegicus Q8R506 63994

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017