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Rho GTPase-activating protein 22

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Protein Overview: Rho GTPase-activating protein 22

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.

Synonyms: Rho-type GTPase-activating protein 22, p68RacGAP

Gene name: Arhgap22

Database References

UniProtID GeneID
Mus musculus Q6QHH6 239027
Homo sapiens A0AVP7 58504

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017