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Rho GTPase-activating protein 24

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Protein Overview: Rho GTPase-activating protein 24

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Synonyms: Rho-type GTPase-activating protein 24

Gene name: Arhgap24

Database References

UniProtID GeneID
Mus musculus Q8C4V1 231532
Homo sapiens Q4KMG1 83478
Rattus norvegicus Q5U2Z7 305156

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017