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Rho GTPase-activating protein 29

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Protein Overview: Rho GTPase-activating protein 29

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.

Synonyms: PTPL1-associated RhoGAP protein 1, Rho-type GTPase-activating protein 29

Gene name: ARHGAP29

Database References

UniProtID GeneID
Homo sapiens O15463 9411
Bos taurus A7YY57 504657
Rattus norvegicus Q5PQJ5 310833
Mus musculus Q3V135 214137
Zebrafish Q6PCS4 378998

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017