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Rho guanine nucleotide exchange factor 1

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Protein Overview: Rho guanine nucleotide exchange factor 1

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Synonyms: Lbc's second cousin

Gene name: Arhgef1

Database References

UniProtID GeneID
Rattus norvegicus Q9Z1I6
Homo sapiens O00513 9138
Mus musculus O89074 16801

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017