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Rho guanine nucleotide exchange factor 25

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Protein Overview: Rho guanine nucleotide exchange factor 25

May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.

Synonyms: Guanine nucleotide exchange factor GEFT, Rac/Cdc42/Rho exchange factor GEFT, RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT

Gene name: Arhgef25

Database References

UniProtID GeneID
Rattus norvegicus Q6P720 314904
Mus musculus Q3TYF3 52666
Homo sapiens A6NJH5

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017