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Rho guanine nucleotide exchange factor 26

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Protein Overview: Rho guanine nucleotide exchange factor 26

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

Synonyms: SH3 domain-containing guanine exchange factor

Gene name: ARHGEF26

Database References

UniProtID GeneID
Homo sapiens Q68CL1 26084

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017