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Rho guanine nucleotide exchange factor 4

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Protein Overview: Rho guanine nucleotide exchange factor 4

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Synonyms: APC-stimulated guanine nucleotide exchange factor, Asef

Gene name: Arhgef4

Database References

UniProtID GeneID
Mus musculus Q7TNR9 226970
Homo sapiens Q9HDC6 50649

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017