auto
Find a product

Rho guanine nucleotide exchange factor 7

(Browse other proteins)

Protein Overview: Rho guanine nucleotide exchange factor 7

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Synonyms: Beta-Pix, PAK-interacting exchange factor beta, p85SPR

Gene name: Arhgef7

Database References

UniProtID GeneID
Mus musculus O08757 54126
Homo sapiens B1ALK6 8874
Rattus norvegicus O55043 114559

Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017