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Ubiquitin-like modifier-activating enzyme ATG7

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Protein Overview: Ubiquitin-like modifier-activating enzyme ATG7

Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3.

Synonyms: ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7

Gene name: ATG7

Database References

UniProtID GeneID
Darling's disease fungus A6QXC6 5450897
Rice blast fungus A4RIA9 2683193
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) A3LPA1 4836974
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) Q6FQY7 2889381
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) A7KAL8 8309771
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Protein Overview data has been sourced from Uniprot Consortium's databases under a Creative Commons Attribution-Commercial license. © 2017