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Monoclonal Mouse anti-CREB1 antibody EMD Millipore #05-667

Product Details

1DB_ID: 1DB-001-0001090562
Company: EMD Millipore
Company product code: 05-667
Product name: Anti-phospho-CREB (Ser133), clone 10E9
Product type: Primary, Antibody
Size/Price: 100 µg/
Target: CREB1
clone: 1.00E+10
Tested applications: ELISA, WB
Host: Mouse
Reacts with: Human, Mouse, Rat, Dog
Clonality: Monoclonal
Immunogen: KLH-conjugated, synthetic peptide (REILSRRP(pS)YR) corresponding to amino acids 125-135 of human CREB. The immunizing sequence is identical in human and mouse. Clone 10E9.
Specificity: Recognizes phosphorylated CREB at Mr 46 kDa. May also recognize p30 and p38 proteins, which likely correspond to phosphorylated CREM and ATF-1 respectively, since the two proteins share significant homology with the phosphorylated CREB immunizing peptide
Isotype: IgG1
Fraction: Kappa
Storage instructions: Stable for 1 year at from date of receipt.
Species Summary: Human, rat, canine and mouse.
Background: CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2.
Alternative Names: active transcription factor CREB, cAMP responsive element binding protein 1, cAMP-response element-binding protein-1, transactivator protein
Subcategory: Epigenetics & Nuclear Function
Gene ID: NM_134442

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Verified publications (1)

Biochem. J., 2010
S6K1 (p70 ribosomal S6 kinase 1) is activated by insulin and growth factors via the PI3K (phosphoinositide 3-kinase) and mTOR (mammalian target of ...
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About EMD Millipore

EMD Millipore Bioscience delivers new technologies & workflow solutions that enable researchers to understand complex biological systems & identify new targets.