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PTEN (human), (recombinant) (His-tag) Enzo Life Sciences #BML-SE402-0010

PTEN (human), (recombinant) (His-tag)

Product Details

1DB_ID: 1DB-001-0001346705
Company: Enzo Life Sciences
Company product code: BML-SE402-0010
Product name: PTEN (human), (recombinant) (His-tag)
Product type: Enzyme
Size/Price: 10 µg/
Enzyme name: PTEN
Source: E. Coli
Species: Human
Background: PTEN (phosphatase and tensin homologue deleted on chromosome 10, MMAC) is a lipid phosphatase which can also act as a tyrosine, serine and threonine protein phosphatase. It is specific for acidic substrates such as phosphatidylinositol(3,4,5)-trisphosphate, which is its main biological substrate that mediates growth factor-induced activation of intracellular signalling through the serine-threonine kinase Akt. The tumor suppressor gene, PTEN, also known as MMAC1 or TEP1, has been isolated from a locus on chromosome 1Oq23; this protein is deleted or mutated in a large number of tumors. Germline mutations of PTEN have been identified in Cowden disease, Lhermitte-Duclos disease, and Bannayan-Zonana syndrome.
Formulation: Liquid. In 50mM TRIS-HCl, pH 8.0, containing 150mM sodium chloride, 5mM DTT, 0.03% Brij 35, 0.1mM EDTA and 20% glycerol.
Application: Study regulation and kinetics of PTEN. Screen for PTEN inhibitors or activators. Postitive control for Western blots.
Long Term Storage: -80°C
Handling: Avoid freeze/thaw cycles. After opening, prepare aliquots, freeze in liquid nitrogen and store at -80°C.
Uniprot ID: PTEN (phosphatase and tensin homologue deleted on chromosome 10, MMAC) is a lipid phosphatase which can also act as a tyrosine, serine and threonine protein phosphatase. It is specific for acidic substrates such as phosphatidylinositol(3,4,5)-trisphosphate, which is its main biological substrate that mediates growth factor-induced activation of intracellular signalling through the serine-threonine kinase Akt. The tumor suppressor gene, PTEN, also known as MMAC1 or TEP1, has been isolated from a locus on chromosome 1Oq23; this protein is deleted or mutated in a large number of tumors. Germline mutations of PTEN have been identified in Cowden disease, Lhermitte-Duclos disease, and Bannayan-Zonana syndrome.

Reviews (1)

4 - Excellent (Publishable / Ideal reagent)
Application: Enzyme assay
Sample: Purified protein
Buffer: Tris 100 mM pH 8, 5mM DTT
Dilution: 100 nM
See all reviews

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About Enzo Life Sciences

BIOMOL International is a brand of Enzo Life Sciences International, Inc., a wholly owned subsidiary of Enzo Biochem. Incorporating the Alexis Biochemicals and BIOMOL brands, Enzo Life Sciences is organized to lead in the development, production, marketing, and sales of innovative life science research reagents worldwide. BIOMOL International has been a leader and an innovator in providing superior, cutting-edge reagents for biomedical research for over 25 years. BIOMOL has been focused on researcher's success since the release of leukotrienes in 1983, through the introduction of the first pathway-specific signal transduction catalog to today's offering of over 3500 products and services. Within Enzo Life Sciences, BIOMOL is a major research, development and production center, developing and producing innovative products for: Signal Transduction, Lipid Signaling, Post Translational Modifications, Proteolysis, and Ubiquitin & Ubiquitin-like Protein Signalling. With production facilities in the Greater Philadelphia region and Exeter, U.K. (formerly AFFINITI Research Products, Ltd.), BIOMOL maintains in-house laboratories staffed with an experienced research & development team of organic chemists, biochemists, cell biologists, pharmacologists and molecular biologists with the expertise to develop and support the innovative products that biomedical research requires. Capabilities include organic chemical synthesis, peptide synthesis, recombinant protein production, antibody production and assay development.