||ELISA, IF, IP, WB
||Human, Mouse, Rat
||c-Jun Antibody (B-1) is a mouse monoclonal IgG1 provided at 200µg/ml raised against a peptide mapping within the N-terminus of c-Jun of mouse origin recommended for detection of c-Jun of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine, porcine and avian TransCruz reagent for Gel Supershift and ChIP applications, sc-166540 X, 200 µg/0.1 ml
||Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, while Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. An inhibitor of Fos/Jun function, termed IP-1, associates with Fos and Jun and is inactivated upon phosphorylation induced by the cAMP-dependent protein kinase A (PKA).
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