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Mouse anti-JUN antibody Santa Cruz Biotechnology, Inc. #sc-166540

Mouse anti-JUN antibody

Product Details

1DB_ID: 1DB-001-0001405280
Company: Santa Cruz Biotechnology, Inc.
Company product code: sc-166540
Product name: c-Jun Antibody (B-1)
Product type: Primary, Antibody
Size/Price: 200 µg/ml/
Target: JUN
clone: B-1
Tested applications: ELISA, IF, IP, WB
Host: Mouse
Reacts with: Human, Mouse, Rat
Description: c-Jun Antibody (B-1) is a mouse monoclonal IgG1 provided at 200µg/ml raised against a peptide mapping within the N-terminus of c-Jun of mouse origin recommended for detection of c-Jun of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine, porcine and avian TransCruz reagent for Gel Supershift and ChIP applications, sc-166540 X, 200 µg/0.1 ml
Isotype: IgG1
Background: Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, while Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. An inhibitor of Fos/Jun function, termed IP-1, associates with Fos and Jun and is inactivated upon phosphorylation induced by the cAMP-dependent protein kinase A (PKA).

Reviews (1)

2 - Poor (Publishable / Would seek higher quality in future)
Application: WB
Sample: Human Lysates
Buffer: PBS
Dilution: 1/1000
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Verified publications (1)

Cancer Immunol. Immunother., 2011
Interleukin-7 is a potent regulator of lymphocyte proliferation, but it inducing growth of solid tumors is few known. We study the relationship ...
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About Santa Cruz Biotechnology, Inc.

Santa Cruz Biotechnology, Inc. is focused on the ongoing development of research antibodies. It is their goal to continue to offer the broadest range of research reagents in the field. They provide superior, innovative primary antibodies and support products.